Regioselective Electrophilic Aromatic Substitution Reactions over Reusable Zeolites

Development of a system for clean and regioselective mononitration of aromatic compounds involving a microporous solid, dinitrogen tetroxide and air{

Electrophilic aromatic substitution reactions are of considerable importance in the production of fine chemicals. However, many traditional processes suffer serious disadvantages, including low selectivity for the desired product and the requirement for large quantities of mineral or Lewis acids as activators. The use of such acids causes plant corrosion and generates large volumes of spent rea...

NH4Br – Br2 Catalysed Oxidative Bromination of Aromatic Compounds

A facile, efficient, simple, environmentally safe, regioselective, controllable and economical method for the oxybromination of aromatic compounds using NH4Br-Br2 system. The electrophilic substitution of bromine generated in situ from NH4Br as a bromine source and molecular bromine as an oxidant.

Tandem buildup of complexity of aromatic molecules through multiple successive electrophile generation in one pot, controlled by varying the reaction temperature.

While some sequential electrophilic aromatic substitution reactions, known as tandem/domino/cascade reactions, have been reported for the construction of aromatic single skeletons, one of the most interesting and challenging possibilities remains the one-pot build-up of a complex aromatic molecule from multiple starting components, i.e., ultimately multi-component electrophilic aromatic substit...

TRIPHENYLPHOSPHINE CATALYZED AROMATIC ELECTROPHILIC SUBSTITUTION OF 2-HYDROXYACETOPHENONE MEDIATED BY VINYLTRIPHENYLPHOSPHONIUM CATION

Protonation of the highly reactive 1:l intermediate produced in the reaction between triphenylphosphine and dimethyl acetylenedicarboxylate by 2- hydroxyacetophenone leads to vinyltriphenylphosphonium salt, which undergoes aromatic electrophilic substitution reaction with the conjugate base to produce compounds 4,5, and 6 in 1 : 1.2:0.5 ratios

Highly regioselective dinitration of toluene over reusable zeolite H